Chromosome Aberrations Induced by High-LET Radiations
نویسندگان
چکیده
منابع مشابه
Quantification of High LET Induced Chromosome Aberrations
The classical cytogenetic assay relies on the scoring of chromosomal damage in cells at metaphase. According to the standard protocol the analysis is confined to cells at the 1st post-irradiation mitosis collected at one, early sampling time. For sparsely ionizing radiation this protocol allows a reasonable estimate of chromosomal damage, because in all commonly used cell system no or only a sl...
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The relative biological effectiveness (RBE) of 252Cf neutrons and synchrotron-generated high-energy charged particles for mutation induction was evaluated as a function of linear energy transfer (LET), using the loss of heterozygosity for wing-hair mutations and the reversion of the mutant white-ivory eye-color in Drosophila melanogaster. Loss of heterozygosity for wing-hair mutations results p...
متن کاملCHROMOSOME ABERRATIONS INDUCED BY LOW DOSES OF LOW- AND HIGH-LET RADIATION: A MODELLING APPROACH F. BALLARINI and A. OTTOLENGHI
Astronauts' lymphocytes taken from post-flight blood samples often show increased levels of chromosome aberrations [1]. CA can be used for risk estimation [2], since specific aberrations are strongly correlated with some cancer types [3]. Furthermore, particular aberration categories can be regarded as biomarkers of the radiation quality [4,5]. Modeling approaches based on track-structure simul...
متن کاملRBE vs. dose for low doses of high-let radiations.
According to track theory, the relative biological effectiveness (RBE) of high linear energy transfer (LET) radiations varies with cellular radiosensitivity parameters and the radiation environment. Of special interest is that the RBE varies as the dose of high-LET radiation to the power (1/m - 1) where m is the "target number" parameter, which varies from 2-4 in different cell lines. This appl...
متن کاملMechanisms for the biological effectiveness of high-LET radiations.
Radiations of high linear energy transfer (LET) have long been known to have greater biological effectiveness per unit dose than those of low LET, for a wide variety of biological effects. However, values of relative biological effectiveness depend considerably on the biological system and in some instances the values are clearly below unity. The differences between high- and low-LET radiations...
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ژورنال
عنوان ژورنال: Biological Sciences in Space
سال: 2004
ISSN: 0914-9201,1349-967X
DOI: 10.2187/bss.18.216